The DTP-HB-Hib vaccine can be given safely and effectively at the same time as BCG, measles, polio (OPV or IPV), and yellow fever vaccines and vitamin A supplementation. In countries where pertussis is of particular danger to young infants, the combination vaccine should be started as soon as possible with the first dose given as early as 6 weeks, and two subsequent doses given at 4-week intervals. IMMUNIZATION SCHEDULE: The vaccine should NOT be used for the birth dose. A sterile syringe and sterile needle must be used for each injection. It must not be injected into the skin as this may give rise to local reaction. An injection into a child's buttocks may cause injury to the sciatic nerve and is not recommended. The anterolateral aspect of the upper thigh is the preferred site of injection. The vaccine should be injected intramuscularly. (See table.)ĪDMINISTRATION: The liquid vaccine vial should be shaken before use to homogenize the suspension. The potency of the vaccine per single human dose is at least 4 IU for pertussis, 30 IU for diphtheria, 60 IU for tetanus (determined in mice), 10 mcg HBsAg and 10 mcg Hib. The polysaccharide is derived from Hib bacteria grown in chemically defined media, and subsequently purified through a series of ultrafiltration steps. Thimerosal 0.05 mg/mL is used as a preservative. The vaccine is adsorbed on to 3 mg/mL aluminum phosphate. The HBsAg is produced by DNA recombinant technology in yeast ( Hansenulla polymorpha) cells. The vaccine is a homogeneous liquid containing purified diphtheria and tetanus toxoids, inactivated whooping cough (pertussis) organisms, highly purified, non-infectious particles of hepatitis B surface antigen (HBsAg) and Hib component as a bacterial subunit vaccine containing highly purified, non-infectious Haemophilus influenzae type b (Hib) capsular polysaccharide chemically conjugated to a protein of tetanus toxoid.
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